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2:22 PM, Anonymous said... My 15-year old border collie/Rott mix was just prescribed 1/2 pill of Tramadol twice a day. He is also on one Anipryl (l-deprenyl) each morning, and a 1/2 Deramaxx pill with evening dinner. (He limps and has trouble with stairs. Vet says he has nerve degeneration of the lower spine called something like, "spando..??). She also thinks he has arthritis and his back left hip may have been dislocated at some point because it twists a little when he walks. Is Tramadol and Anipryl safe together???? You say it's contraindicated.thankskaren
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Nancy Campbell RVT said... Contraindicated means that it is "not advised" when certain conditions exist. Domitor, though a good sedative, most vets I know, do not use Domitor on dogs over the age of 7 years.Domitor is a sedative, I assume they're using it to keep her sedated after her surgery and the hydromorphone is for pain control. It's been my experience that the analgesic effect of Domitor has been minimal at best. They probably do not want to use the Tramadol because it is an oral drug and oral drugs are not recommended after surgery. There are other injectable options available though.Is the hospital aware of your dogs liver condition? Make sure they know so that they can consider changing their protocol or advise you as to why they feel confident using it on her.
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Click here for more information on
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7:43 PM, me said... Tramadol does have addiction potential that specialists are finding of enough concern for humans that they provide other opiate type drugs while steering clear of tramadol. Animals cant obtain their own supplys to feed a psychological addiction. Psychological addiction is the only definition of the word addiction. Physical dependence is normal and needs to be considered with many drugs including anti depressants. Saying tramadol isnt addictive is untrue and simplifies what addiction is, which leads to greater misunderstanding and fear of using beneficial drugs. When tramadol, paxil and many other drugs came out they were touted as non addictive and with the least side effects. We know now that was a marketing lie. Paxil's withdrawl syndrome now has black box warnings for children and teenagers for risk of suicide while taking that medication. If tramadol works well for animals, wonderful, but it is a newer drug then most reliable opiates and experience has shown in humans that it isnt a safer drug addiction wise to opiates.
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5:52 PM, Anonymous said... Today was sort of a "two steps forward, one step back" kind of day. We had some more squealing, particularly when you have to pick him up. (Which unfortunately is not an optional thing, we live in a two story house and there are even three steps down from the front porch to the yard.) We also had him do some squealing this morning as well.However, he moved his bowels today, and seemed much more alert and even did some trotting in the yard. Before, he would just go in the yard, pee without raising his leg, and then collapse in the lawn and just lay there sprawled out. He seems more like himself, but he is still hurting from time to time.We go to the lower dosage of prednisone tomorrow (1 a day vs 2 a day) and I would have liked to have seen more improvement. But I am trying to be patient.I'll post again when there is a change, hopefully for the better.-TSGreenville, SC
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Tramadol has been shown to be embryotoxic and fetotoxic in mice, (120 mg/kg or 360 mg/m²), rats (≥25 mg/kg or 150 mg/m²) and rabbits (≥75 mg/kg or 900 mg/m²) at maternally toxic dosages, but was not teratogenic at these dose levels. These dosages on a mg/m² basis are 1.4, ≥0.6, and ≥3.6 times the maximum daily human dosage (246 mg/m²) for mouse, rat and rabbit, respectively.
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8:38 PM, Susan in Montana said... I have a question about Tramodoland Deramaxx, too, I guess. My vet had prescribed Deramaxx for our 10-year-old Golden Retriever's arthritis and I had been giving him the maximum dose since last summer. A few weeks ago I took him in to the vet. They did some blood tests and discovered elevated creatinin, indicating decreased kidney function. We did two more blood tests after that, finding that his creatinin was indeed elevated. The vet took him off the Deramaxx and put him on Tramadol. I am concerned because some websites say that Tramadol is not good if a dog has compromised kidney function. I am noticing also that he is now drinking more wateris this a good sign or a bad sign? Is the decreased kidney function from the use of Deramaxx permanent? Thanks so much for your help.
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According to the System to Retrieve Drug Evidence (STRIDE), a federal database for the seized drugs analyzed by DEA forensic laboratories, there were 23 drug items of tramadol from 11 different cases in 2006. These items included 239 tablets and 9.17 grams of powder. According to the National Forensic Laboratory System (NFLIS), state and local forensic laboratories analyzed 4,785 exhibits of tramadol in 2006.
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Pain intensity scores were comparable at any time (table2) but patients in the Propacetamol (P) group needed significantly more morphine than the Tramadol (T) group to relive their pain (8.50 ± 5.15 vs. 4.75 ± 4.9; P=0.025).
... Comment #256: tramadol hcl apap 375 ...Nancy Campbell RVT said... You'll need to ask your vet. There are so many alternatives for pain control that I think it is best left up to your vet to decide what would be best for your pet. Sorry, I couldn't be of more help.
Riedel F, von Stockhausen H-B. Severe cerebral depression after intoxication with tramadol in a 6-month-old infant. Eu J Clin Pharmacol 1984;26:631-632.
Abdominal or stomach conditions (severe)—Tramadol may hide signs of other medical conditions.Addiction problems orSuicidal—Tramadol should not be used. Alcohol or drug abuse, or history of—May increase the serious side effects of tramadol.Epilepsy orHistory of seizuresIncreased risk for seizures caused by alcohol and drug withdrawal, brain or spinal cord infections, or head trauma—Risk of seizures may be increased. Head injury—Tramadol can hide signs of other medical conditions. Kidney disease orLiver disease—The chance of side effects may be increased. Your doctor will consider this when deciding on your doses.
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In peri- and post-natal studies in rats, progeny of dams receiving oral (gavage) dose levels of 50 mg/kg or greater had decreased weights, and pup survival was decreased early in lactation at 80 mg/kg (6 to 10 times the maximum human dose). No toxicity was observed for progeny of dams receiving 8, 10, 20, 25 or 40 mg/kg. Maternal toxicity was observed at all dose levels, but effects on progeny were evident only at higher dose levels where maternal toxicity was more severe.
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For many people, pain is a part of daily life. Since ancient times, people have tried various remedies to relieve pain, including the use of medicinal herbs and even surgery. Narcotics like opium became popular as pain relievers in the nineteenth century. Even heroin has a history of use as a pain medication. In fact, it was originally developed for that purpose. Of course, narcotics are addictive and they have many adverse side effects, including digestive problems, and severe mood disturbances. Narcotics can also interfere with breathing. A better alternative was needed.
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Christie Keith said... "Anonymous" wrote:Saying tramadol isnt addictive is untrue and simplifies what addiction is, which leads to greater misunderstanding and fear of using beneficial drugs.I did not really say "Tramadol isn't addictive." I said that Tramadol can relieve pain without sedation and without addiction. It CAN sedate and it CAN be addictive. There is no question of that. But it's still true that it can be used to relieve pain without addiction and without sedation. Perhaps that's a fine distinction but it IS a distinction.The only real issue with Tramadol's addictiveness in animals is that we remember to withdraw them carefully from longterm use. As you noted, dogs do not rob convenience stores to buy drugs on the streets, nor do they figure out how to scam their vets to get prescriptions for painkillers that they don't really need. If tramadol works well for animals, wonderful, but it is a newer drug then most reliable opiates and experience has shown in humans that it isnt a safer drug addiction wise to opiates.Tramadol is not a "newer drug." It's a generic drug and has been on the market a long, long time. It has many definite advantages over both NSAIDs and narcotics such as morphine and fentanyl (which are themselves hugely addicting and sedating, even at lower dosages), and fills a need for a drug that can be used in dogs with renal complications. It is extremely safe, has a very wide dosage range, and is standing between life and death for many dogs with pain that can't be controlled with NSAIDs, or for whom NSAIDs are not appropriate. Morphine and fentanyl have their place, especially for post-surgical pain and end-of-life pain for cancer, but Tramadol can actually be used for chronic pain. It can be used for years. There really is no other drug that fills this niche, and I don't believe we can fairly dismiss it or cloud its use with dire warnings of addiction - especially when the alternatives to Tramadol, for dogs who cannot take NSAIDs or for whom NSAIDs only are not enough, are drugs that are far MORE addictive and not appropriate for longterm use for chronic pain.This doesn't mean I entirely disregard the addiction potential of Tramadol. I simply think it's a very minor issue for this drug and in this species. And replacing it with heavy narcotics certainly won't help!
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2:13 PM, Anonymous said... My dog was biten by a copperhead a few hours ago. I could not aford the pain medication the Dr. offered(what college student could) but I did get the antbiotics. I have been prescribed Tramadol can I give him one or will it react with the venom. The vet said something about having to give an opiate based pain med so it would not react with the venom. Isn't tramadol a synthetic opiate?
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4:02 PM, Anonymous said... My yorkie is 4 1/2 years old. He had neuro surgery last June for COMS/syringomyelia. This is an awful disease. He has been on pred now for over a year, I cannot wean him off due to pain. He is also on liquid neurontin 3 times a day. My local vet spoke with the neurologist a few months ago when none of the above was controlling Noahs pain. They added Tramadol. It is a 50 mg tab and I was told to give 1/4 prn for pain. Lately we have had more bad nights than good. I have had to give 1/2 tab instead of 1/4 for 2 days now. Today he had BM which had fresh blood also. I am trying not to freak as otherwise he appears okay. I jsut found this website and saw nothing about GI Bleed. So any history of such? Does Tramadol come in another dosing size that would be easier to measure. Noah use to be 4 pounds, now with all the pred he is at 9. I know this is weight is too much but I can't get him off it with the steriods. I also wonder if he may have developed Hemorrhoids due to the weight/pressure when squatting to poop? Any thoughts?FYI the tramadol has been our saving grace many nights when he is hurting so bad, it kicks in within 20-30 minutes and he finally wll have peace.AD Alabama
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How to use Tramadol Oral Take this medication by mouth with or without food as directed by your doctor. If you have nausea, you may take this drug with food. Consult your doctor or pharmacist about other ways to decrease nausea (e.g., antihistamines, lying down for 1 to 2 hours with as little head movement as possible).The dosage is based on your medical condition and response to treatment. To reduce the risk of side effects, your doctor may tell you to gradually increase your dose when starting tramadol.The maximum recommended dose is 400 milligrams a day. If you have serious kidney disease (e.g., if you are on dialysis), the maximum recommended dose is 100 milligrams every 12 hours. If you have serious liver disease (e.g., cirrhosis), the maximum recommended dose is 50 milligrams every 12 hours. If you are older than 75 years, the maximum recommended dose is 300 milligrams a day.Pain medications work best if they are used as the first signs of pain (or migraine) occur. If you wait until the pain has worsened, the medication may not work as well.Follow your doctor's or pharmacist's instruction for the safe use of non-narcotic pain relievers (e.g., acetaminophen, ibuprofen). Ask your doctor or pharmacist for more details regarding your treatment.This medication may cause dependence, especially if it has been used regularly for an extended time or if it has been used in high doses. In such cases, withdrawal reactions (e.g., anxiety, sweating, sleeplessness, shaking, diarrhea, rapid breathing) may occur if you suddenly stop this drug. Also, if you are taking regular doses of narcotic medications for ongoing pain (e.g., cancer pain), starting tramadol may cause a withdrawal reaction. To prevent withdrawal reactions when stopping extended, regular treatment with this drug, gradually reduce the dosage as directed. Consult your doctor or pharmacist for more details, and report any withdrawal reactions immediately.Rarely, abnormal drug-seeking behavior (addiction) is possible with this medication. Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed.When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.Tell your doctor if your pain persists or worsens.
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Nancy Campbell RVT said... How much does your Irish Setter weigh? I've not heard any reason why a dog wouldn't be able to remain on Tramadol, if it is helping with pain.
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Do not crush the tramadol tablet. This medicine is for oral (by mouth) use only. Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhalation or injection can cause life-threatening side effects, overdose, or death. Do not crush, chew, break, or open a controlled-release, delayed-release, or extended-release tablet or capsule. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time. If you use the tramadol extended-release tablet, the tablet shell may pass into your stools (bowel movements). This is normal and does not mean that you are not receiving enough of the medicine.
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Take tramadol exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor. Do not take more than 300 milligrams of tramadol in one day.
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