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expensivewino13 said... I am very relieved to read this thread, also. My American bulldog had patellar lux surgeries at 18 months of age and recuperated very well. However, at the age of 7 years, he's showing a bit of arthritis in his hips. I have kept him slim all these years and we walk him, and we give him double doses of Free and Easy, which is a wonderful supplement.We also have stair on order for him to get onto our bed now. He should not be jumping off anything at his age (fused cervicals - wrist injuries). I am looking at a way to get Meloxicam (Metacam) without a prescription, and this is the best news ever!I've found many places to get the tramadol (without the acetamenophin) online, and life will be so much better here.Incidentally, we just got a puppy, and I think our dog is also a bit depressed. Dogs are just like kids, jealous....My comment is that when Gator's time comes to go, there will be no way that I can put him through more pain that is necessary. Some of the people in this thread seem mislead as to what they're doing to their dogs. If anyone knows the pain of loss, I do. I've lost many beloved pets over the years. We rescue everything.And when we lose Gator, it will be the worse loss ever. This dog is my best friend, my shadow, my road trip partner, the first face I see in the morning and the last one I see at night. I've slept with him every night since he came to us, with the exception of crate training.And to think of keeping him around in pain longer than he should be here because I can't let him go would be the worst kind of karma. Selfish karma.I think some of you dog owners need to really consider why you're keeping your dogs around. It's hard to let go, but when a dog has so many problems - the rollercoaster they encounter going to the vets, recouperating, getting injured again - keeping them alive may be cruel.I just had to say that. We live next to an idiot who won't put her rottie down, and I've become very sensitive to these dogs. Her life is hell. Her shoulder vertebrae are fused because her dyspasia is so bad. She whimpers, cries, shakes, and pants. Her life is not good.Maybe, when you dog gets to this point where it's on so many meds and is over ten, you should be thankful for the wonderful decade you've had and allow the pet its final dignity - to go peaceful and not after a drawn-out, torturous, elderly life stage.
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Date review completed: 1995 Number of trials included: 18 Number of patients: 3453 (1486 tramadol / 695 placebo) Control group: oral placebo Main outcomes: pain relief at 6 hours (TOTPAR), Number-needed-to-treat (NNT) (with 95% confidence intervals) and relative benefit (with 95% confidence intervals). Inclusion criteria were single oral dose, randomised, placebo-controlled, double-blind trials of tramadol in acute postoperative pain with sufficient data to calculate the area under the curve for pain relief (TOTPAR). Baseline pain was moderate to severe. The 6 hour TOTPAR was calculated for each patient, and the data were converted to the percent of maximum total pain relief from categorical pain scales (%maxTOTPAR), and then to dichotomous information to generate a number-needed-to-treat for at least 50% pain relief. Relative benefit was calculated to provide an assessment of how much more likely an individual given a particular treatment is to have at least 50% pain relief than someone given no treatment. Adverse effects frequency data were used to calculate numbers-needed-to-harm and relative risk.
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suz said... Hi, my 8yr old golden was just diagnosed with "soft tissue" sarcoma in her front right elbow.We are devestated,we are waiting on some more precise diagnosis but we have been told they feel it is a very aggressive type sarcoma. Bottom line amputation would probably only be a temporary fix and we will lose her anyway. We are just not ready to put her down, but we love her so much we don't want her to be in pain. Do you think Tramadol .50mg every 4-6hrs, combined with Rimadyl twice a day is enough for her pain. I just cant handle the thought of her suffering. Wish there was a pill for broken hearts. My 3yr. old twins keep telling me they "dont want her to go to heaven." Heartbreaking. Thanks for any advice. Suz
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Nursing Mothers Ultram is not recommended for obstetrical preoperative medication or for post-delivery analgesia in nursing mothers because its safety in infants and newborns has not been studied. Following a single 100 mg dose of tramadol, the cumulative excretion in breast milk within 16 hours postdose was 100 µg of tramadol (0.1% of the maternal dose) and 27 µg of M1.
A slight, but statistically significant, increase in two common murine tumors, pulmonary and hepatic, was observed in a mouse carcinogenicity study, particularly in aged mice (dosing orally up to 30 mg/kg for approximately two years, although the study was not done with the Maximum Tolerated Dose). This finding is not believed to suggest risk in humans. No such finding occurred in a rate carcinogenicity study.
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4:01 AM, Anonymous said... Human prescribing information suggests that when immediate relief is not required, side effects can be reduced by starting Tramadol in small doses and increasing it incrementally at 3-day intervals until a therapeutic dosage is reached. I wish I'd done this with my dog. He is 14 y/o with severe arthritis including impinged nerve roots in both the cervical and lumbar spine. He's healthy otherwise. We're just giving him pain relief as long as he's with us. Unfortunately he's had problems with all the NSAIDs he's tried. We recently started hiim on Tramadol. For the first 3-4 days he was so sedated that he hardly moved - and when he did he was really clumsy - and I think the inactivity really aggravated the pinched nerve in his neck. His lifespan is in days or at most weeks anyhow (pray for him, our other dog, and his human family - thank you) but in another situation I might've been pretty upset about the new med permanently aggravating the problem it was intended to treat.
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Click here for more information on
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Diane said... Hi, I noticed someone commented on their dog panting when they gave them Tramadol. My dog a 9 year old Great Pyrenees has Fibrosarcoma and my Vet has him on this. He also pants quite a bit and the meds seem to keep him up with the panting. I was wondering if I could give him Benedryl to help him sleep. Thanks!!
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Nancy Campbell RVT said... You'll need to ask your vet. There are so many alternatives for pain control that I think it is best left up to your vet to decide what would be best for your pet. Sorry, I couldn't be of more help.
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Take tramadol exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor. Do not take more than 300 milligrams of tramadol in one day.
Tramadol is used to relieve moderate to moderately severe pain. It also may be used to treat pain caused by surgery and chronic conditions such as cancer or joint pain. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
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MedicineNet®Copyright © 2007 by RxList Inc.RxList does not provide medical advice, diagnosis or treatment.
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2:19 PM, Anonymous said... Well,I didn't realize that I hadn't updated this. Hopefully you will understand why...I am "TS" who had the 5lb Pomeranian with back pain. Our early diagnosis was a probable slipped disk. When it didn't get better with prednisone and tramadol, we did an x-ray and the doctor suspected discospondylitis - a spinal infection.We treated with antibiotics for 10 days and weren't seeing any improvements. We did another x-ray and that is when our world fell apart. There were very big changes in the vertebra in just 10 days. We went back to prednisone and tramadol, with the assumption that it was probably bone cancer - relatively rare in a small dog in the vertebra. It was very aggressive and we turned up the prednisone and tramadol very high.He tolerated this very well and we got about a month and a half before we noticed a signficant change. Another x-ray showed that the vertebra had completely collapsed and we decided it was time. He couldn't really walk on his back legs and the spinal cord was making a stair-step path through the disintegrated vertebra and the doctor told us that when it finally got pinched good as the spine collapsed, it would be terribly painful. We didn't want to get to that point, so we called it quits and had to let our little guy go.It was the most painful thing I have ever experienced in my life. That was on July 20th and today is Sept 25th and I have tears in my eyes as I type this here.My wife and I held him in our arms as they did the injections, the first to put him to sleep, and the second to stop his heart. I would say to those who can't stay in the room, don't worry - it is peaceful. They don't feel a thing.It is you that is left to hurt - but at least they aren't hurting any more.We made it four days with my wife crying to sleep every night, dreading waking up to an empty house after I had gone to work.We now have a 4 month old Pomeranian who is exactly like our previous dog in one way - he LOVES PEOPLE. But other than that, he is different in about every other way - which is good. We didn't replace our little buddy, but we had to fill that hole in our hearts with a new little friend.-TSGreenville, SC
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Nancy Campbell RVT said... If I were in your shoes I would find a new 24/7 hospital pronto. There's no point in dealing with vets you don't trust. Even if you have to drive several hours, wouldn't it be worth the peace of mind?
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4 In comparative studies in postoperative and post-trauma pain, tramadol 100 mg intramuscularly or intravenously was equivalent to 5–10 mg of morphine. However, in severe pain associated with either surgery or cancer, morphine was more effective than tramadol and remains the drug of choice. In acute and chronic non-malignant pain, oral tramadol 100 mg is comparable to a combination of paracetamol and codeine (1000 mg/60 mg). There have been few direct comparisons of tramadol with non-steroidal anti-inflammatory drugs, but efficacy appears to be similar.
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I medicated myself with Tramadol which is easily accessable a few miles south of me in Tijuana, MX without prescription for around $20 for 50 tablets. I created an expensive habit but I have decided I don't like myself this way. My 4 hour habit makes me quick to irritation with my children, no motivation, constipation! I AM ADDICTED and I am smart enough to recognize it. I took my last 5 pills 48 hours ago and last night was the worst experience of my life. Sleeplessness, agitation, thoughts of suicide, diorrhrea, chills, skin crawls, heat flashes and sweats and that was just at night. During the day, I feel weak, tired, and truly fearful of another night like that. Natalie - San Diego, California, USA
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Nancy Campbell RVT said... Suz, the best relief for your friend is likely to be amuputation. The dose you mentioned for Tramadol is 1/10 of a pill so I'm am assuming you meant 50mg and with the Rimadyl which helps with any inflammation *some* relief may be afforded, but not what amputation is more apt to give. My heart goes out to you and your family. May you find peace and love in the days to come.
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... Comment #148: tramadol side effects in dogs rapid breathing ...arthritis. These medications act by inhibiting cyclo-oxygenase (abbreviated "COX"), an enzyme that leads to production of assorted inflammatory biochemicals. Suppressing this enzyme, suppresses the pain as well as the inflammation. Unfortunately, cyclo-oxygenase also helps produce some much needed biochemicals and it becomes tricky to suppress production of inflammatory products while keeping the helpful ones. Occasionally, a dog will develop a reaction to one of these anti-inflammatory medications or will develop a liver or kidney problem which is incompatible with their use. These dogs still require pain management and for these patients, a mu agonist like tramadol may be just the ticket.
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7:28 PM, Anonymous said... Great page. I have a 12 year old pomeranian that weighs about 5.5 lbs. He recently had several large teeth removed. He was prescribed tramadol orally after the surgery to control the pain. It was mixed into an oral suspension (I supposed because of the small size of the dog, in order to get the dosage right) and I was supposed to give .25 ml of a 100mg/5ml solution twice a day. So if I am doing my math right, that is 5mg per dose, 10mg per day.My dog has responded well to the surgery and was up and around very quickly and we are seeing no signs of infection or problems with the teeth. There was some scratching on his face as the stitches dissolved but never to the point of causing any problem and he seems to have cut way back on the scratching now.I took him off the tramadol within a couple of days because he seemed fine. However, we have noticed signs of mild constipation during the first week.This week it has gotten worse. He squeals in pain when you pick him up and he has gone two days without a bowel movement. He is eating lightly, but perhaps a little less than normal. He hasn't quit eating entirely though and still seems to enjoy Pupperoni Treats (What do they put in those things, cocaine? He goes nuts for them) if we break them into pieces.The squealing and screeching is extremely unnerving. He is so scared of being picked up that he squeals when you even act like you might be about to pick him up. It is heartbreaking, but also very frustrating because I don't know how much is pain, and how much is fear.I took the dog to the vet today and as you might expect, he did almost none of what I described above while we were at the office. The vet was able to get one light squeak out of him and that was it. The vet suggested doubling the dose of tramadol to manage the pain and tapering it off over the weekend to see if that helped.I mentioned the decreased number of bowel movements to our doctor, but at the time of the visit, it was a day and a half without a movement which is abnormal (he usually has one a day) but not extreme.Now it is 10pm and we are at two straight days and we spent a good deal of time outside walking him and trying to coax him into having a bowel movement to no avail.This leads me to believe that his problems may be gastrointestinal in nature and when we pick him up we are pressing on his belly and hurting him. It also leads me to my long-winded question: Should I continue the tramadol since it seems to have a slight incidence of constipation and it doesn't seem to be helping the pain.Also, off topic for this thread, but what is my best step on the constipation?Thanks for any help,-TS
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Click here for more information on
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7:56 PM, agilitydogmom said... Hi Nancy,Thanks so much for your reply. I was able to reach my vet and she authorized giving my dog up to 1/2 a 50 mg tramadol every four to six hours as needed. That really knocked down the pain and life is much more bearable for her now. Of course the leg still hurts like mad if it gets moved or bumped, but she seems to be able to rest comfortably. So far I am really impressed with this med. Even at that high dose she is not out of it. It does make her a little sleepy, which in her current condition is probably a good thing. But she can still get up and navigate properly to go out to go to the bathroom. Every day she seems a little better and I am now giving the pills every six hours instead of every four hours.My vet did say that Tramadol at high dosage is likely to cause constipation, but I feel like that's not nearly as bad of a problem as being in horrible pain. The pain patch you asked about had been applied that morning so it may not have reached full strength yet, which probably contributed to the difficult first night she had.Thanks again, your tramadol page was really helpful to me!
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piloerection, and rarely hallucinations. Other symptoms that have been seen less frequently with ULTRAM discontinuation include:
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ULTRAM may induce psychic and physical dependence of the morphine-type ( -opioid) (see
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Kesavan S, Sobala GM. Serotonin syndrome with fluoxetine plus tramadol. J R Soc Med 1999;92:474-5.
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synapses. Drugs that reduce neurotransmitter activity are called
Office of National Drug Control Policy was created for central coordination of drug-related legislative, security, diplomatic, research and health policy throughout the government. In recognition of his central role, the director of ONDCP is commonly known as the
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long-term depression (LTD). Using mice as a model, Kourrich, ‘’et al’’, displayed that chronic exposure to cocaine increases the strength of synapses in NAc after a 10-14 day withdrawal period, while strengthened synapses did not appear within a 24 hour withdrawal period after repeated cocaine exposure. A single dose of cocaine did not display any attributes of a strengthened synapse. When drug experienced mice were challenged with one dose of cocaine, synaptic depression occurred. Therefore, it seems the history of cocaine exposure along with withdrawal times affects the direction of glutamatergic plasticity in the NAc.
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The molecular weight of tramadol hydrochloride is 299.8. Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The water/n-octanol partition coefficient is 1.35 at pH 7. Ultram tablets contain 50 mg of tramadol hydrochloride and are white in color. Inactive ingredients in the tablet are corn starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and wax.
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