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1:54 PM, Anonymous said... Well, my Beagle is having the same problems TS. She has a two narrowed disc spaces and we are trying our best to treat this at home.She is on Tramadol (3 -50 mg pills a day), Predisone (2 pills a day for 5 days and then 1 pill a day for 5 days). I do give her a 1/4 pill of Pepcid A/C with the Predisone, the neurologist seems to think it will help with any vomitting problems that could arise.All she has done is sleep. Which is great because for the past 5 days she has been panting, shivering and whining. Now we have not been able to get her to go BM. She never lost movement and her reflexes are great so the Dr. thought the disc was just putting very light pressure on the cord itself.I hope your pup gets better and I hope mine will to. It is so hard to see your baby in pain.
Usually, however, drug classification under such legislation is not related simply to addictiveness. The substances covered often have very different addictive properties. Some are highly prone to cause physical dependency, whilst others rarely cause any form of compulsive need whatsoever. Also, under legislation specifically about drugs,
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Tramadol is a novel analgesic having both opiate agonist activity and monoamine reuptake inhibition that contribute to its analgesic efficacy. Opioid activity is due to both the parent compound and the more active O-desmethylated metabolite. Tramadol acts on the monoamine reuptake systems by inhibiting the reuptake into nerve terminals of both norepinephrine and serotonin. Apart from analgesia, tramadol may produce a number of symptoms including dizziness, somnolence, nausea, and constipation similar to other opioids. High doses of tramadol, often in combination monoamine oxidase (MAO) inhibitors or serotonin-selective reuptake inhibitors (SSRIs), have been associated with a serotonin syndrome consisting of convulsions, hyperthermia, muscle rigidity and pain.
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4:42 AM, Anonymous said... First, thanks for the great info on this site. Our 14-year old lab/shep mix (75lbs) has severe arthritis in all four joints (dysplasia in hips, arthritis and swelling in front). He's very stoic, and doesn't whimper or cry, but in the last year, he's starting having a much more pronounced limp, and atrophy in the back, crossing of legs which indicates neurological problems, etc. At night (and often daytime too) he'd get very wrestless, panting, walking, panting, walking, looking to us for help, then panting and walking some more and he couldn't seem to calm down. (We tried Anapryl for adult cognative issues but it didn't help). His problem, of course, was that he was in pain, and the pain made him upset and anxious because he needed help. To treat that, the doctor prescribed Acepromazine as a sedative / anti-anxiety med and Tramadol for pain. For all of you out there with dogs who pant and pace and pant and pace, then lie down for three seconds and get right back up to pant and pace talk to your vet about Acepromazine. It reeeeeally helps calm them down so they can rest and let the pain meds do what they're supposed to do. Pain meds alone didn't do it for him, but the combination of Tramadol and Acepromazine has worked miracles.Acepromazine can be very sedating, so it takes some trial and error to find the right dosing. You want them comfortable but not comatose. He's sort of sleepy a lot, but he is 14, so he'd sleep a lot anyway. He gets up when we come in the door, and gets excited when the doorbell rings, he'll switch rooms and lie down near my husband or I depending on his mood, and take a nap there for a while. So he still enjoys life. He eats well, and even went to the dog park a couple of weeks ago for 15 minutes or so and had a great time smelling all the smells. This would not have been possible without the combination of these two meds.His regimin is: - 75mg Rimadyl 2xday; - 75mg Tramadol 2xday1 Lasix in morning (heart congestion which is controlled with Lasix)- 1/2 tablet Acepromazine breakfast, one whole tablet at dinner.- glucosamine/chondroitin 2xday - Fish oil 1xday (to help lubricate joints, help digestion, and build antioxidants)-Vitamin E 1xday (because fish oil can deplete Vitamin E)*****Also, for anyone who has trouble giving pills to your dog, try sticking the pills down into a small piece of hot dog. They'll eat it right up. With all the pills my guy gets, this has been a godsend!!Anyway, maybe this info will be helpful. I was at my wits end with the pacing and panting. he seemed desperate and I couldn't help him. Now it's very rare we have a night of pacing problems, annd as soon as we see it coming on, we give him a bit of extra meds and it calms him right back down and eases the pain so he can enjoy his night. For us, it's all about keeping him comfortable and happy as long as he's with us, and this has made a huge difference the last year. Good luck to others!Good luck.
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The decision to prescribe tramadol should not be a trivial one. Tramadol has a place in pain management for selected patients who have not responded to simple analgesics such as paracetamol or aspirin and in whom NSAIDs are contraindicated. For most patients, a combination of paracetamol and codeine will be equally effective and possibly better tolerated than tramadol. In order to minimise adverse effects, patient factors should be carefully considered and the patient’s medication history must be carefully reviewed.
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Age: Healthy elderly subjects aged 65 to 75 years have plasma tramadol concentrations and elimination half-lives comparable to those observed in healthy subjects less than 65 years of age. In subjects over 75 years maximum serum concentrations are slightly elevated (208 vs. 162 ng/ml) and the elimination half-life is slightly prolonged (7 vs. 6 hours) compared to subjects 65 to 75 years of age. Adjustment of the daily dose is recommended for patients older than 75 years (see DOSAGE AND ADMINISTRATION).
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Nancy Campbell RVT said... It is listed as contraindicated on the label. I suggest you talk to a pharmacist or your vet. If your vet doesn't know you might suggest he talk to someone in the pharmacy department of a veterinary school or if they're a member of VIN he could post the question there.
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if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription (especially depression medicines) or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you are allergic to codeine, a codeine-related medicine (eg, hydrocodone, dihydrocodeine, oxycodone), morphine, or a morphine-related medicine (eg, hydromorphone) if you have a history of alcohol abuse, substance abuse, or suicidal thoughts or behaviors if you have or recently have had any head injury, brain injury or tumor, increased pressure in the brain, or infection of the brain or nervous system if you have a history of stomach or intestinal problems, asthma or other lung or breathing problems, epilepsy, seizures, or chronic inflammation or ulceration of the bowels if you have had recent abdominal surgery if you have heart problems, liver problems (eg, hepatitis), kidney problems, thyroid problems, enlargement of the prostate gland, or urinary problems Some MEDICINES MAY INTERACT with Tramadol . Tell your health care provider if you are taking any other medicines, especially any of the following:
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For the subset of patients for whom rapid onset of analgesic effect is required and for whom the benefits outweigh the risk of discontinuation due to adverse events associated with higher initial doses, Tramadol 50 mg to 100 mg can be administered as needed for pain relief every four to six hours, not to exceed 400 mg per day.
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Click here for more information on
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Overdose may manifest as seizures, pinpoint pupils, and mental alterations. Seek veterinary assistance at once should any of these occur. If a pet develops apparent sedation or bizarre behavior, the tramadol dose should be reduced.
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Drug addiction is a state of periodic or chronic intoxication produced by the repeated consumption of a drug (natural or synthetic). Its characteristics include: (i) an overpowering desire or need (compulsion) to continue taking the drug and to obtain it by any means; (ii) a tendency to increase the dose; (iii) a psychic (psychological) and generally a
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1:54 PM, Anonymous said... Well, my Beagle is having the same problems TS. She has a two narrowed disc spaces and we are trying our best to treat this at home.She is on Tramadol (3 -50 mg pills a day), Predisone (2 pills a day for 5 days and then 1 pill a day for 5 days). I do give her a 1/4 pill of Pepcid A/C with the Predisone, the neurologist seems to think it will help with any vomitting problems that could arise.All she has done is sleep. Which is great because for the past 5 days she has been panting, shivering and whining. Now we have not been able to get her to go BM. She never lost movement and her reflexes are great so the Dr. thought the disc was just putting very light pressure on the cord itself.I hope your pup gets better and I hope mine will to. It is so hard to see your baby in pain.
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Seizures have been reported in patients receiving ULTRAM within the recommended dosage range. Spontaneous post-marketing reports indicate that seizure risk is increased with doses of ULTRAM above the recommended range. Concomitant use of ULTRAM increases the seizure risk in patients taking:
The major metabolic pathways appear to be N- and O- demethylation and glucuronidation or sulfation in the liver. One metabolite (O-desmethyltramadol, denoted M1) is pharmacologically active in animal models.
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Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
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Kathy said... Last week my dog could not get up so I called my vet. She said to give the dog Tramadol HCI 50 mg which I did. But I also gave the dog a previcox tablet for arthritis. Well, by that evening she begged to go out and I let her without supervision and she got into the neighbor's garabage! The next day she had diarrhea so I cut off the medicine. Our vet was also trying to determine if Lucy had Cushing Disease. The next day my dog died and I don't know if I mixed the wrong medicines, the dog got into the wrong garbage or the Cushing Disease did her in. She's had symptoms of the disease for over a year. I think she died of a heart attach because her chest heaved several times. What do you think she died of?
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Side effects from treatment with tramadol may be decreased by a slow increase in dose, as directed by your doctor. The tablets can easily be broken in half at the score if needed. The maximum dose of tramadol for an average healthy adult is 100 mg per dose, every 4 to 6 hours, up to 400 mg per day. People over 75 years of age should not take more than 300 mg per day. People with liver or kidney disease may need lower daily doses. Follow your doctor's directions.
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Tramadol may only be temporary and might subside throughout the course of taking tramadol. those side effects may include: dizziness, nausea, drowsiness, dry mouth, constipation, headache, or sweating. If these side effects do continue or are becoming bothersome, be sure to check with your doctor. If any of the following occur, be sure to check with your doctor as soon as possible: skin rash, itching, seizures, or hallucinations. If you notice other side effects not listed above, make sure to contact your doctor, nurse, or pharmacist.
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Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
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Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, headache, or weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you are taking tramadol regularly, it may be useful to start using a laxative right away instead of waiting until you become constipated. Consult your pharmacist for details regarding the correct use of laxatives (e.g., stimulant-type with stool softener).Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes, unusual/extreme stiffness in the muscles, shaking (tremor), severe stomach/abdominal pain, change in the amount of urine, vision changes.Tell your doctor immediately if any of these rare but very serious side effects occur: slow/shallow breathing, seizures, fever/flu-like symptoms.A very serious allergic reaction to this drug (which may occur as early as the first dose) is rare. However, seek immediate medical attention if you notice any of the following symptoms: rash, itching, swelling (especially of the lips, tongue, or throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
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Plasma concentrations of racemic tramadol are predictable over a 50 mg to 100 mg single-dose range. This is also true under multiple-dose conditions. Steady state is achieved after two days of dosing Ultram by a 100 mg q.i.d. regimen (maximum plasma concentration was 592 ± 177 ng/ml). The plasma half-life of tramadol following a single and multiple dosing was 6 and 7 hours, respectively. This increase in half-life upon multiple dosing is not considered to be clinically significant or to warrant dosage adjustment for chronic use.
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