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Con las primeras dosis de tramadol puede aparecer náuseas y vómitos que suelen desaparecer si se tumba durante un rato. Si estos efectos continúan, consulte a su médico o farmacéutico.
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cody said... I myself am a vet tech, but am looking for more opinions on helping my 14yr old, 93lb. mixed breed dog. She has had arthritis issues for about 7yrs now. One repaired acl, one not(just crate rest for 2wks for partial tear). She has been on several NSAID's and adequan injections for about 4yrs. Lately she has progressed further, and upon x-ray we found severe lubosacral stenosis, and arthritis in both hips, hocks and stifles. She is "knuckling" and losing control of her bowels. I tried tramadol to no effect- 50mg bid because she has elevated liver enzymes and is in a fragile state(also living w/an incompletely excised MCT for one yr. with no recurrence:). She was on previcox for over a year and i just recently switched to metacam b/c previcox seemed to be losing it's effectiveness. I tried prednisone- at a very very low dose (5mg bid) and she did great but absolutely cannot tolerate the drug. Severe aggitation, urinated on herself twice and ravenously hungry) I do know these are symptoms as I am a tech but they were severe with my dog. Unfortunately it worked the best. I even tried a natural hydrocortisone- same symptoms to a slightly lesser degree. I am desperate to give her relief- she is still very much alive in spirit. Have you any experience with amantadine or neurontin? Anything at all I could use in place of pred??? thanks so much!
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Nancy Campbell RVT said... Tramadol is very bitter and unpleasant. Drooling is something dogs (and cats) will do if they get a taste it.
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In our study, although pain intensity score was comparable between the two groups at any time, patients in the Propacetamol group needed considerably higher dose of morphine for pain control (8.50 + 5.15 vs. 4.75 + 4.9;P = 0.025) than Tramadol group. It seems that equal pain control in the Propacetamol group was achieved at the expense of more morphine consumption. Need for rescue medication was also more in the Propacetamol group, as 10 patients (50%) in this group needed additional morphine compared to 3 patients (15%) in the Tramadol group (P= 0.041).
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Tramadol is well absorbed orally. It can be administered in 50 to 100 mg tablets as needed for pain relief every 4 to 6 hours, not to exceed 400 mg/day. Seizures have occurred in patients taking recommended doses but are more likely at high doses associated with abuse of this medication. Tolerance, dependence and addiction to tramadol have been demonstrated. Abrupt cessation from tramadol has been associated with two types of withdrawal syndromes. One is typical of opioid drugs with flu-like symptoms, restlessness and drug craving. This type of withdrawal syndrome is encountered in about 90 percent of cases of withdrawal from tramadol. Another withdrawal syndrome (encountered in about 10 percent of cases of tramadol withdrawal) is atypical of opioids and is associated with hallucinations, paranoia, extreme anxiety, panic attacks, confusion, and numbness and tingling in the extremities.
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Christie Keith said... Obviously we can't know for sure what is going on with your dog. In general, I'd say that it IS hard to know if this is an opioid response (Tramadol is sort of an opioid and sort of not)or if it's from pain. Usually, this kind of opioid response is accompanied by whining and a lack of recognition of the owner. In fact, whining is the single symptom the first vet who prescribed Tramadol to a dog of mine warned me about, as being from too high a dose for that dog. I have never seen it from Tramadol, but I have seen it from Fentanyl and from morphine. This does not sound like what your dog is experiencing, however.Sometimes we do see dogs whose owners say they are "sedated" when what they are is finally getting some deep sleep because their pain is under control. This does not at all sound like what you are describing, either.So, the answer is ... you need to talk to a vet who IS familiar with Tramadol and with pain management. This will be easy. Your vet can simply call and do a consult with any vet school's anesthesia consultants. They will be able to tell him how to evaluate the effect of this drug on your dog.Your vet also could go onto VIN (if he or she is not already a member, they can obtain a free 30 day trial membership; www.vin) and consult with the analgesia/anesthesia consultants there. It sounds to me like your dog is in a lot of pain and really needs some expert pain management here. Fortunately, that IS available, even if your own vet isn't an expert in that area. Please let us know how he does!Christie and Nancy
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The molecular weight of tramadol hydrochloride is 299.8. Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The water/n-octanol partition coefficient is 1.35 at pH 7. Ultram tablets contain 50 mg of tramadol hydrochloride and are white in color. Inactive ingredients in the tablet are corn starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and wax.
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Do not stop using this medication suddenly without talking to your doctor. You may need to gradually reduce the dose. Withdrawal symptoms may occur when you stop using tramadol. Withdrawal symptoms include anxiety, sweating, nausea, diarrhea, tremors, chills, hallucinations, trouble sleeping, or breathing problems. Call your doctor at once if you have any of these withdrawal symptoms after you stop using tramadol.
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In single-dose models of pain following oral surgery, pain relief was demonstrated in some patients at doses of 50 mg and 75 mg. A dose of 100 mg Ultram tended to provide analgesia superior to codeine sulfate 60 mg, but it was not effective as the combination of aspirin 650 mg with codeine phosphate 60 mg. In single-dose models of pain following surgical procedures, 150 mg provided analgesia generally comparable to the combination of acetaminophen 650 mg with propoxyphene napsylate 100 mg, with a tendency toward later peak effect.
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Tramadol is used to treat moderate to severe pain. Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.
Christie Keith said... I'm so glad you came back with an update! Please let us know how she does!I didn't think it could possibly be the Tramadol, glad you sought out a new vet.
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[46] but rather than substituting for alcohol these drugs are intended to reduce the desire to drink, either by directly reducing cravings as with acamprosate and topiramate, or by producing unpleasant effects when alcohol is drunk, as with disulfiram. These drugs can be effective if treatment is maintained, but compliance can be an issue as alcoholic patients often forget to take their medication, or discontinue use because of excessive side effects.
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For the treatment of painful conditions Ultram (tramadol hydrochloride) 50 mg to 100 mg can be administered as needed for relief every four to six hours, not to exceed 400 mg per day. For moderate pain Ultram 50 mg may be adequate as the initial dose, and for more severe pain Ultram 100 mg is usually more effective as the initial dose.
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Ultram is indicated for the management of moderate to moderately severe pain.
15 However, tramadol should be used with caution in patients with a history of epilepsy and those on concomitant seizure threshold-lowering medication (e.g. tricyclics, selective serotonin re-uptake inhibitors, high dose opioids).
1:54 PM, Anonymous said... Well, my Beagle is having the same problems TS. She has a two narrowed disc spaces and we are trying our best to treat this at home.She is on Tramadol (3 -50 mg pills a day), Predisone (2 pills a day for 5 days and then 1 pill a day for 5 days). I do give her a 1/4 pill of Pepcid A/C with the Predisone, the neurologist seems to think it will help with any vomitting problems that could arise.All she has done is sleep. Which is great because for the past 5 days she has been panting, shivering and whining. Now we have not been able to get her to go BM. She never lost movement and her reflexes are great so the Dr. thought the disc was just putting very light pressure on the cord itself.I hope your pup gets better and I hope mine will to. It is so hard to see your baby in pain.
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¿Cómo se utiliza? En España existen comercializadas formas de administración oral (comprimidos retard, cápsulas, cápsulas retard, gotas y solución), parenteral (intramuscular, subcutánea, intravenosa) y rectal (supositorios). La dosis adecuada de tramadol puede ser diferente para cada paciente. A continuación se indican las dosis más frecuentemente recomendadas, pero si su médico le ha indicado otra dosis, no la cambie sin consultar con él o con su farmacéutico.
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(+/-)-Tramadol is a synthetic analogue of codeine. It is a central analgesic with a low affinity for opioid receptors. Its selectivity for mu receptors has recently been demonstrated, and the M1 metabolite of tramadol, produced by liver O-demethylation, shows a higher affinity for opioid receptors than the parent drug. The rate of production of this M1 derivative (O-demethyl tramadol), is influenced by a polymorphic isoenzyme of the debrisoquine-type, cytochrome P450 2D6 (CYP2D6). Nevertheless, this affinity for mu receptors of the CNS remains low, being 6000 times lower than that of morphine. Moreover, and in contrast to other opioids, the analgesic action of tramadol is only partially inhibited by the opioid antagonist naloxone, which suggests the existence of another mechanism of action. This was demonstrated by the discovery of a monoaminergic activity that inhibits noradrenaline (norepinephrine) and serotonin (5-hydroxytryptamine; 5-HT) reuptake, making a significant contribution to the analgesic action by blocking nociceptive impulses at the spinal level. (+/-)-Tramadol is a racemic mixture of 2 enantiomers, each one displaying differing affinities for various receptors. (+/-)-Tramadol is a selective agonist of mu receptors and preferentially inhibits serotonin reuptake, whereas (-)-tramadol mainly inhibits noradrenaline reuptake. The action of these 2 enantiomers is both complementary and synergistic and results in the analgesic effect of (+/-)-tramadol. After oral administration, tramadol demonstrates 68% bioavailability, with peak serum concentrations reached within 2 hours. The elimination kinetics can be described as 2-compartmental, with a half-life of 5.1 hours for tramadol and 9 hours for the M1 derivative after a single oral dose of 100mg. This explains the approximately 2-fold accumulation of the parent drug and its M1 derivative that is observed during multiple dose treatment with tramadol. The recommended daily dose of tramadol is between 50 and 100mg every 4 to 6 hours, with a maximum dose of 400 mg/day; the duration of the analgesic effect after a single oral dose of tramadol 100mg is about 6 hours. Adverse effects, and nausea in particular, are dose-dependent and therefore considerably more likely to appear if the loading dose is high. The reduction of this dose during the first days of treatment is an important factor in improving tolerability. Other adverse effects are generally similar to those of opioids, although they are usually less severe, and can include respiratory depression, dysphoria and constipation. Tramadol can be administered concomitantly with other analgesics, particularly those with peripheral action, while drugs that depress CNS function may enhance the sedative effect of tramadol. Tramadol should not be administered to patients receiving monoamine oxidase inhibitors, and administration with tricyclic antidepressant drugs should also be avoided. Tramadol has pharmacodynamic and pharmacokinetic properties that are highly unlikely to lead to dependence. This was confirmed by various controlled studies and postmarketing surveillance studies, which reported an extremely small number of patients developing tolerance or instances of tramadol abuse. Tramadol is a central acting analgesic which has been shown to be effective and well tolerated, and likely to be of value for treating several pain conditions (step II of the World Health Organization ladder) where treatment with strong opioids is not required.
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This summary of a Cochrane review presents what we know from research about the effect of tramadol for osteoarthritis. The review shows that:
8:08 AM, Anonymous said... Is tramadol a good fit for bursitis? I have an almos 11 year-old greyhound, approx. 80#. He has chronic bursitis in his shoulder. It seems to give him quite a bit of pain, either limping profoundly and/or refusing to put weight on the leg while standing. He also pants a lot, especially in the evening. He is currently taking deramaxx but he still pants and my sense is that the deramaxx is relieving the pain some, but not completely. The bursitis seems to get better for a while, and about the time he seems pretty normal in his movements, starts the heavy limping and panting again. I'm wondering if adding tramadol to the deramaxx would be a good protocol for this condition. Are there any other treatments for this condition that I could pursue. What do you think about homeopathic remedies, ointments, etc.?
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Ultram was administered to 550 patients during the double-blind or open-label extension periods in U.S. studies of chronic nonmalignant pain. Of these patients, 375 were 65 years old or older. TABLE 1 reports the cumulative incidence rate of adverse reactions by 7, 30 and 90 days for the most frequent reactions (5% or more by 7 days). The most frequently reported events were in the central nervous system and gastrointestinal system. Although the reactions listed in the table are felt to be probably related to Ultram administration, the reported rates also include some events that may have been due to underlying disease or concomitant medication. The overall incidence rates of adverse experiences in these trials were similar for Ultram and the active control groups, Tylenol with Codeine #3 (acetaminophen 300 mg with codeine phosphate 30 mg), and aspirin 325 mg with codeine phosphate 30 mg. (TABLE 1)
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Before taking long-acting tramadol, tell your doctor or pharmacist if you are allergic to it; or to other narcotics (e.g., codeine); or if you have any other allergies.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., respiratory depression, hypercapnia), intoxication with drugs that depress the nervous system or your breathing (CNS/respiratory depressants such as alcohol or tranquilizers/sedatives), certain mental/mood conditions (e.g., thoughts of suicide), abuse of drugs/alcohol.Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain bowel diseases (paralytic ileus), brain disorders (e.g., seizures, increased intracranial pressure), conditions that increase the risk of seizures (e.g., head injury, brain tumors, meningitis, metabolic disorders, alcohol/drug withdrawal), adrenal gland problem (e.g., Addison's disease), difficulty urinating (e.g., due to enlarged prostate, urethral narrowing), heart problems (e.g., irregular heartbeat), personal or family history of regular use/abuse of drugs/alcohol, kidney disease, liver disease, lung diseases (e.g., chronic obstructive pulmonary disease-COPD, hypoxia), disease of the pancreas (e.g., pancreatitis), mental/mood conditions (e.g., major depression, toxic psychosis), a certain spinal problem (kyphoscoliosis), stomach/intestinal problems (e.g., gallbladder disease), underactive thyroid (hypothyroidism).This drug may make you dizzy or drowsy. Use caution while driving, using machinery, or doing any activity that requires alertness. Avoid alcoholic beverages because they may increase the risk of this drug's side effects.To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Before having surgery, tell your doctor or dentist that you are using this medication.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially slow/shallow breathing and drowsiness.During pregnancy, this medication should be used only when clearly needed. It is not recommended for use for long periods or in high doses late in pregnancy because of possible serious harm to your baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended time may have seizures or withdrawal symptoms such as irritability, abnormal/persistent crying, or diarrhea. Tell your doctor immediately if you notice any of these symptoms in your newborn.This drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.
... Comment #70: tramadol for canines side effects ...Drug Abuse and Intervention
tell your doctor and pharmacist if you are allergic to tramadol or other opiate pain or cough medications such as meperidine (Demerol), morphine (Avinza, Kadian, MS Contin), codeine (in some pain medications and cough syrups), hydrocodone (in Vicodin), hydromorphone (Dilaudid), oxycodone (OxyContin, in Percocet), propoxyphene (Darvon, Darvon N, in Darvocet), any other medications, or any of the ingredients in tramadol tablets or extended-release tablets. Ask your pharmacist for a list of ingredients in tramadol tablets or extended release tablets. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: antifungal medications such as ketoconazole (Nizoral); digoxin (Lanoxin); erythromycin (E.E.S., E-Mycin, Erythrocin); monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for anxiety, mental illness, nausea, and pain; medications for seizures, such as carbamazepine (Tegretol); muscle relaxants such as cyclobenzaprine (Flexeril); promethazine (Phenergan); quinidine; rifampin (Rifadin, Rifamate, Rimactane, others); sedatives; sleeping pills; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); tranquilizers; tricyclic antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil);and warfarin (Coumadin). Many other medications may also interact with tramadol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor what herbal products you are taking, especially St. John's wort. tell your doctor if you have or have ever had seizures; an infection in your brain or spine; a head injury, a brain tumor, a stroke, or any other condition that caused high pressure inside your skull; depression or thoughts about harming or killing yourself or planning or trying to do so; diabetes; breathing problems or lung disease; or kidney or liver disease. Also tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking tramadol, call your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tramadol. you should know that this medication may make you drowsy and may affect your coordination. Do not drive a car or operate machinery until you know how this medication affects you. talk to your doctor about the safe use of alcohol while you are taking this medication. Alcohol can make the side effects from tramadol worse. you should know that tramadol may cause dizziness, lightheadedness, and fainting when you get up from a lying position. To avoid this, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
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