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dub49tfw said... Thanks. I have a 39 pound 13 year old mixed breed border collie. She has had liver disease with elevated liver functions though a biopsy showed significant inflamagtion without fibrosis - without cirrhosis. She has been on prednisone and Imuran for the hepatitis. She has used tramadol, 15 mg evey 8 hrs approximately for control of what may be painful partial tear of anterior cruciate ligament in hind leg and tendinous extension or relaxation because of the prednisone. She's been very lethargic and recent reduction in appetite (which I understand can be side effect of Imuran). Does this dose of tramadole generally contribute to sedation and lethargy? Thanks Gene Du Boff
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Mark-Fancy Cats Rescue said... Has Tramadol been used in cats?Also has anyone any experience in dosing Tamiflu for feline panleukopenia?
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9- Duthie DJR. Remifentanil and Tramadol: recent advances in opioid pharmacology. Br J Anesth 1998; 81: 51-57.
Despite these claims, it is apparent in community practice, that dependence to this agent does occur.
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"ULTRAM may induce psychic and physical dependence of the morphine-type (µ-opioid). Dependence and abuse, including drug-seeking behavior and taking illicit actions to obtain the drug are not limited to those patients with prior history of opioid dependence. The risk in patients with substance abuse has been observed to be higher. ULTRAM is associated with craving and tolerance development. Withdrawal symptoms may occur if ULTRAM is discontinued abruptly."
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Use Tramadol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
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Nancy Campbell RVT said... Sorry I didn't respond sooner. I've had a full plate the past few weeks. I'm glad you took your dog to another vet. It sounds like you had far better communication with the new one and you were able to help your dog better. Good luck and good healing.
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The analgesic effects of tramadol are not completely reversed by the opioid antagonist naloxone and some patients who do not respond to codeine do respond to tramadol. This suggests that tramadol has additional mechanisms of action. Tramadol inhibits reuptake of serotonin and noradrenaline and this probably contributes to its analgesic effects.
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Tramadol is well absorbed orally. It can be administered in 50 to 100 mg tablets as needed for pain relief every 4 to 6 hours, not to exceed 400 mg/day. Seizures have occurred in patients taking recommended doses but are more likely at high doses associated with abuse of this medication. Tolerance, dependence and addiction to tramadol have been demonstrated. Abrupt cessation from tramadol has been associated with two types of withdrawal syndromes. One is typical of opioid drugs with flu-like symptoms, restlessness and drug craving. This type of withdrawal syndrome is encountered in about 90 percent of cases of withdrawal from tramadol. Another withdrawal syndrome (encountered in about 10 percent of cases of tramadol withdrawal) is atypical of opioids and is associated with hallucinations, paranoia, extreme anxiety, panic attacks, confusion, and numbness and tingling in the extremities.
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3:03 PM, Anne-Marie said... This summer we adopted a senior (the vet estimates about 14-years old) dog who was found wandering the woods in rural Virginia. When we adopted "Annabelle" in June she was, basically, a mess. She'd had heartworm and lyme disease and was very thin (she weighed 35 pounds at the time she now weighs 47 pounds and is still thinner than I'd like...) She also had arthritis and some sort of spine problem - she could barely walk. Since adopting her in June, we've learned of other medical problems -kidney disease, high blood pressure and glaucoma. Anyway, the GOOD news is, that our vet and a team of specialists have found what appears to be the perfect balance of drugs and diet and she's doing absolutely great!! She takes Tramadol for the pain and that's made a huge difference in her ability to get around. She almost runs sometimes! They'd initially had her on Rimadyl but when we discovered her kidney problems, had to discontinue that. And the Rimadyl didn't really seem to help her much anyway - not like what we're seeing with the Tramadol. She's been on Tramadol for over 6 months now and hasn't had any problems or side effects with it. We're thrilled.
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Since tramadol is taken on an as-needed basis, missing a dose is usually not a problem. Take the dose as soon as you remember, and do not take another dose for the amount of time prescribed by your doctor. Do not take a double dose of this medication.
Incidence less than 1%, possibly causally related: the following lists adverse reactions that occurred with an incidence of less than 1% in clinical trials and/or reported in post-marketing experience.
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Paracetamol (acetaminophen) is a safe and effective analgesic that is used for relieving mild to moderate pain. Tramadol, a synthetic opioid of aminocyctohexanol group, is an analgesic with central effect and weak opioid agonistic properties. This drug is also effective on noradrenergic and serotonergic neurotransmission. The aim of this study was to compare the analgesic and side effects of Propacetamol (Prodafalganª,UPSA, France) and Tramadol (Aburaihan Pharmaceutical, Iran) after urologic open surgeries. A total number of 40 surgical patients were prospectively randomized into two equal groups of 20 and were entered into single blinded clinical trial. Anesthesia protocol was similar for all patients. Pain intensity was measured based on a 4point verbal rating scale (VRS). VRS was obtained before analgesic administration (T0) and at 0.5, 1.5, 3, 4.5, 6, 12, 18 and 24 hours.
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Nancy Campbell RVT said... How much does your Irish Setter weigh? I've not heard any reason why a dog wouldn't be able to remain on Tramadol, if it is helping with pain.
International Statistical Classification of Diseases and Related Health Problems (ICD), no longer recognise 'drug abuse' as a current medical diagnosis. Instead, they have adopted
8:38 PM, Susan in Montana said... I have a question about Tramodoland Deramaxx, too, I guess. My vet had prescribed Deramaxx for our 10-year-old Golden Retriever's arthritis and I had been giving him the maximum dose since last summer. A few weeks ago I took him in to the vet. They did some blood tests and discovered elevated creatinin, indicating decreased kidney function. We did two more blood tests after that, finding that his creatinin was indeed elevated. The vet took him off the Deramaxx and put him on Tramadol. I am concerned because some websites say that Tramadol is not good if a dog has compromised kidney function. I am noticing also that he is now drinking more wateris this a good sign or a bad sign? Is the decreased kidney function from the use of Deramaxx permanent? Thanks so much for your help.
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Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, headache, or weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you are taking tramadol regularly, it may be useful to start using a laxative right away instead of waiting until you become constipated. Consult your pharmacist for details regarding the correct use of laxatives (e.g., stimulant-type with stool softener).Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes, unusual/extreme stiffness in the muscles, shaking (tremor), severe stomach/abdominal pain, change in the amount of urine, vision changes.Tell your doctor immediately if any of these rare but very serious side effects occur: slow/shallow breathing, seizures, fever/flu-like symptoms.A very serious allergic reaction to this drug (which may occur as early as the first dose) is rare. However, seek immediate medical attention if you notice any of the following symptoms: rash, itching, swelling (especially of the lips, tongue, or throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
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Metrebian N, Shanahan W, Wells B, Stimson GV. Feasibility of prescribing injectable heroin and methadone to opiate-dependent drug users: associated health gains and harm reductions. Medical Journal of Australia. 1998 Jun 15;168(12):596-600.
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10- Schaffer J, Hagemann H, Holzapfel S, Panning B, et al. Investigation of Tramadol for post-operative analgesiain children. Forschr Anesth 1998; 3: 42-45.
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Dejonckheere et al also assessed the efficacy of Tramadol and Propacetamol for pain after thyroidectomy and found that although both needed equal supplementary morphine, pain relief in the Tramadol group was better than that of the other group and although more patients in the Tramadol group experienced nausea and vomiting during the first 2 hours after operation, the difference during the whole time of the study was not significant (14).
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6:31 PM, Anonymous said... We are seeing noticable improvments today. Our dog is still tender and will even squeal pretty good when he wakes up from a nap, or gets up too fast - but his behavior is markedly different. He seems so much more like his usual self. He had been going into a bathroom on the ground floor and sleeping most of the day. Tonight he came out and wanted to be on the couch with us again while we watched TV.We go to one prednisone per day now, and I have been easing back on the tramadol with only 4mg (instead of 5mg) per dose now. I'll try to ease that down as we get near the 14 days so that we run less of a risk of withdrawal symptoms. I'll update again in a few days or if anything changes.
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Tramadol tomorrow. With Rimadyl, she takes 75mg twice a day. Tramdol is prescribed at 50mg from 1-4 times a day PRN. My dog weighs approx 70 pounds.
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DOSING: The recommended dose of tramadol is 50-100 mg (immediate release tablets) every 4-6 hours as needed for pain. The maximum dose is 400 mg/day. To improve tolerance patients should be started at 25 mg/day, and doses may be increased by 25 mg every 3 days to reach 100 mg/day (25 mg 4 times daily). Thereafter, doses can be increased by 50 mg every 3 days to reach 200 mg day (50 mg 4 times daily). Tramadol may be taken with or without food.
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Despite these claims, it is apparent in community practice, that dependence to this agent does occur.
Food and Drug Administration offers a 180 day exclusivity period to generic drug manufacturers in specific cases. During this period only one (or sometimes a few) generic manufacturers can produce the generic version of a drug. This exclusivity period is only used when a generic manufacturer argues that a patent is invalid or is not violated in the generic production of a drug, and the period acts as a reward for the generic manufacturer who is willing to risk liability in court and the cost of patent court litigation. There is often contention around these 180 day exclusivity periods because a generic producer does not have to produce the drug during this period and can file an application first to prevent other generic producers from selling the drug.
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El tramadol puede provocar somnolencia y visión borrosa. No se aconseja la conducción de vehículos ni el manejo de maquinaria peligrosa o de precisión, especialmente durante los primeros días de tratamiento.
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